Chunk #73 — Methods — Simulations

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Adjustment for index event bias in genome-wide association studies of subsequent events.

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yes

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We estimated bias and mean-square error across SNPs in the same ways. Since we simulated genetic effects with mean zero, Eq. (3) shows that the mean signed bias will be zero across SNPs, although individual SNPs will have non-zero bias. Therefore, we estimated the mean absolute bias across SNPs.