The average response rate across trials (n=7) for SRI and non-active comparison conditions were 50% and 25%, respectively. A random effects meta-analysis identified a moderate effect for SRIs relative to comparison conditions (RR=1.80, 95% CI: 1.43, 2.26, z=5.06 p<0.001) with minimal heterogeneity [Q(6)=6.89, p=0.33, I2=12.88%] (Figure 3). The NNT for SRI treatment response was five. Visual inspection of the funnel plot and Egger’s test for bias indicated that publication bias was present (t=4.46, p=0.006). When Duval and Tweedie’s trim-and-fill method was applied, four studies were trimmed and SRIs still exhibited a moderate effect (RR=1.52, 95%CI: 1.18, 1.95). All trials with treatment response data used a placebo control condition.
