Previous studies [7], [15], [16] have reported that genes that undergo dosage differences due to the presence (proximity) of CNVs show an enrichment for genes involved in immune response and response to external biotic stimuli. We identified an olfactory receptor gene OR6J1 and a gene DAD1 (defender against cell death 1), both on chromosome 14, that are trans-regulated genes for the tCNV CNVR5165.1 on chromosome 11. We found an overrepresentation for target genes involved in the calibrated molecular response to stimulus (whether chemical stimulus or potential internal or invasive threat). Our novel observation in this regard is that previously reported enrichment for genes relevant for molecular-environmental interactions generalizes to the target genes for tCNVs as eCNVs.
