Permutation tests, as described in section 2.4.2 were carried out to determine whether the intramodal and intermodal correspondences between association trajectories were SNP-specific, with the null hypotheses that they were not. These tests were applied to the data of the coarse-grained analysis. It should be noted that these tests depend on the heterogeneity of the timing of effects between SNPs, and would be more accurate if there were more SNPs.