A subsample of 2000 of the most heavily phenotyped participants will have complete genome sequencing to 6-fold depth (UK10K and Sanger Institute). For 1000 participants, ALSPAC has obtained gene expression data (Illumina 48 k chip) and copy number variation data (custom 105 k Agilent CGH chip from the WTCCC). DNA methylation data sampling (Illumina HumanMethylation450 BeadChip) is being run on 1000 mother and child pairs (where mother and child DNA is available from all of the following: child DNA at birth, 7 or 9 mean years of age and 15 or 17 mean years of age and mother DNA from pregnancy and child aged 15–17 years); and also whole-methylome sequencing is currently being piloted.
