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Chunk #2 — Introduction

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Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel.
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Improved call rates can be achieved by aggregating information across many samples through the use of phasing methods that estimate the underlying haplotypes of the study samples. Inference of the underlying haplotypes dictates the genotype calls of each sample. This builds on the idea that over small genomic regions, the samples will share haplotypes due to local genealogical relationships, leading to a per-haplotype coverage much higher than the per-individual coverage.