We used publicly available results of GWAS for known obesity complications, including type 2 diabetes15, lipid levels16 and coronary artery disease (CAD)17,18, to assess the impact of the newly discovered obesity loci on these traits. Two of the loci were associated with diabetes15: GNPDA2 (P = 6.6 × 10−5) and TMEM18 (P = 7.5 × 10−4) (Supplementary Table 8). Most of the BMI-associated variants were not significantly associated with these BMI-related traits, most likely because of low power to detect very small effects in the public datasets and the incomplete correlation between BMI and these traits19.
