activation of the mesocorticolimbic system that are mainly comprised of the AMY, the NAc, the PFC, and the VTA [45]. That is to say, the above pathways for drug addiction or synaptic function can also mediate the rewarding effect of alcohol or are essential for neuroadaptive processes triggered by alcohol. Accordingly, AUD-associated miRNAs identified in the above eight brain regions are expected to regulate the expression of genes that are important for alcohol-induced neuroadaptations.
