Chunk #23 — Results — Pascal has higher power than hypergeometric test based pathway enrichment in a wide range of traits

Source

Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics.

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When splitting the GWAS into high powered (more than 50,000 individuals) and low powered studies (less than 50,000 individuals), we saw that in both cases we gain power by using Pascal although the effect was more pronounced for low powered GWAS (S7 Fig).