Results of this calculation are found in Panel C of Supplementary Table 17. For DEP, NEUR, and SWB, respectively, we anticipated increases in predictive power of 0.21, 0.56, and 0.39 percentage points. All three anticipated increases are within their respective estimated confidence intervals: [0.04, 0.31], [0.16, 0.61], and [0.12, 0.65]. Overall, the observed gains in predictive power relative to conventional GWAS-based polygenic scores are thus consistent with theoretical expectations.
