confirm statistically-significant association at the level of individual gene loci, assuming that subsequent followup analyses will use further steps to untangle any locus heterogeneity, to unequivocally identify which individual SNPs are associated, to identify pathological haplotypes and the phases with which they are associated with phenotypes in samples from different racial and ethnic backgrounds. Indeed, our belief that, in many circumstances, molecular biologic, behavioral and other evidence will be required to have confidence in pathological haplotypes allows the analyses that we present here to represent open door invitations for just these sorts of ancillary studies to guide further molecular genetic fine mapping efforts.
