the brain (via the high affinity compound Spiegelmer NOX‐B11‐2), there is no subsequent attenuation of the rewarding properties of alcohol in rodents (Jerlhag et al. 2014). Taken together with previous experiments, the importance of central GHSR‐1a receptors in drug‐induced reward was raised. It is thus possible that the minor allele of the rs2948694 alters the sensitivity of the cholinergic‐dopaminergic reward link, which in turn may lead to a predisposition to smoking and increased alcohol consumption, reflected by the higher AUDIT scores in the present study.
