be linked with an activity shift from internal to external information processing networks (Tanabe et al., 2011). In contrast, a model of nicotine effects during abstinence based on resting state FC results suggests a shift in network dynamics towards endogenous information processing represented by the DMN where the insula plays an important salience role (Sutherland et al., 2012). The evidence points to abnormal interactions due to nicotine addiction between brain networks of exogenous (executive control) and endogenous (DMN) attention regulated by a third salience network anchored in the insula (Fedota and Stein, 2015).
