We aimed to explore the hypothesis that some form of natural selection is linked to the maintenance of common genetic risk in schizophrenia12,84,85. To do this, for all SNPs included in the CLOZUK + PGC meta-analysis summary statistics, we obtained four different genome-wide metrics of positive selection (iHS86, XP-EEH87, CMS88 and CLR28), one of background selection (B statistic29, postprocessed by Huber et al.28) and one of Neanderthal introgression (average posterior probability LA89). The use of different statistics is motivated by the fact that each of them is tailored to detect a particular selective process that acted on a particular timeframe (see Vitti et al.51 for a review). For example, iHS and CMS are based on the inference of abnormally long haplotypes and thus are better powered to detect recent selective sweeps that occurred during the last ~30,000 years88, such as those linked to lactose tolerance or pathogen response90. On the other hand, CLR incorporates information about the spatial pattern of genomic variability (the site frequency spectrum91) and corrects explicitly for evidence of BGS, thus being able to detect signals from
