SNPs at three loci (MLXIPL, TRIB1, and CILP2/PBX4) were significantly associated with triglycerides in at least one non-white ethnic group. SNPs rs17321515 near MLXIPL and rs17145738 near TRIB1 replicated in Mexican Americans (P = 0.01 and 7.1 × 10−5, respectively). In non-Hispanic blacks, we observed an association between rs3734991 near CILP2/PBX4 and triglycerides (P = 0.01). LPL rs328 was strongly associated with triglycerides in non-Hispanic whites (P = 0.0002). SNPs at the remaining four loci failed to replicate in either non-white ethnic group.