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Chunk #18 — Results — Triglycerides

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Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III.
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SNPs at three loci (MLXIPL, TRIB1, and CILP2/PBX4) were significantly associated with triglycerides in at least one non-white ethnic group. SNPs rs17321515 near MLXIPL and rs17145738 near TRIB1 replicated in Mexican Americans (P = 0.01 and 7.1 × 10−5, respectively). In non-Hispanic blacks, we observed an association between rs3734991 near CILP2/PBX4 and triglycerides (P = 0.01). LPL rs328 was strongly associated with triglycerides in non-Hispanic whites (P = 0.0002). SNPs at the remaining four loci failed to replicate in either non-white ethnic group.