on the basis of gene expression patterns in the adult mouse brain using the Allen Brain Atlas31 (Supplementary Fig. 5 online). Fifth, we correlated module eigengenes with available sample information such as cortical area, age or gender. Using these approaches, we identified modules of coexpressed genes with characteristics of PVALB-positive interneurons, Purkinje neurons, microglia and meningeal cells; other modules described mitochondrial, ribosomal and synaptic function, response to hypoxia, and gender differences (Supplementary Note online). We also identified a module consisting of genes that are specifically coexpressed in the subventricular zone (SVZ), one of two regions where neurogenesis is known to persist in the adult brain39,40 (see below). In addition, we found that module characterization revealed significant evidence for genomic clustering of coexpressed genes related to glutamatergic synaptic function in human cerebral cortex, particularly on chromosome 19 (P = 3.2 × 10−18 (CTX) and P = 1.2 × 10−14 (CTX_95); Supplementary Table 8 and Supplementary Note; graphical depictions of all modules from CTX, CN and CB are presented in Supplementary Fig. 4).
