The study, including the protocols for subject recruitment and assessment; the Informed Consent for participants (and Assent Forms for those 14–18 y); and the overall analysis plan was reviewed and approved by institutional review boards for the Istituto di Neurogenetica e Neurofarmacologia (INN; Cagliari, Italy), for the MedStar Research Institute (responsible for intramural research at the National Institutes of Aging, Baltimore, Maryland, United States) and for the University of Michigan (Ann Arbor, Michigan, United States).
