The power calculations were performed utilizing Genetic Power Calculator (http://pngu.mgh.harvard.edu/~purcell/gpc/).21 All of the association analyses were performed using a generalized linear (logistic) model with PLINK v1.07 (http://pngu.mgh.harvard.edu/~purcell/plink/)22 with age and sex and the 10 first multidimensional scaling clusters as covariates. The meta-analyses with fixed effect model were performed with GWAMA software (http://www.geenivaramu.ee/en/tools/gwama.23 SPSS (IBM Released 2013. IBM SPSS Statistics for Windows, Version 22.0. Armonk, NY, USA). The linkage disequilibrium (LD) and haplotype analyses were performed utilizing PLINK v1.07, Haploview,24 and SNAP (https://www.broadinstitute.org/mpg/snap/).25 Detailed description of the statistical analyses can be found in the Supplementary Information.
