Chunk #75 — Methods — Parkinson’s disease post-mortem transcriptomes

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Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease.

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gene expression in the substantia nigra, we only kept cell types that are present in the substantia nigra or ventral midbrain for our EWCE 11 analysis. We computed a new specificity matrix based on the substantia nigra or ventral midbrain cells from the Zeisel dataset (level 5) using EWCE 11. The EWCE analysis was performed on the 500 most up or down regulated genes using 10,000 bootstrapping replicates.