is underpowered since the GWAS does not use Alzheimer’s disease cases but, rather, subjects who have a first-degree relative with Alzheimer’s disease as “cases”. Nevertheless, we were able to replicate (at a nominal P < 0.05) seven of our IGAP TWAS associations in the UKBB TWAS (Fig. 5c). These two complementary replication efforts demonstrate the robustness of our results. Finally, we performed a TWAS using the summary statistics of a meta-analysis of IGAP and UKBB GWAS, and identified three additional genes (ABCA7, RHBDF1, and VPS53) that meet a genome-wide significant threshold in the meta-analysis, with ABCA7 being one of the well-validated Alzheimer’s disease loci (Supplementary Table 12).
