Many markers with q < 0.50 were evaluated only in the AFR group due to low MAC in other groups. Given that most alcohol-related GWAS have been conducted on samples of European ancestry, these markers were largely unavailable for replication attempts in other samples. Had we calculated q-values based only on markers available in the EUR group, or only on those available across all groups, the list of markers for follow-up would have differed, potentially impacting the overall outcome of the SNP-based replication assessments.
