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Chunk #14 — Materials and Methods — Measures — Alcohol Sensitivity

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Associations of OPRM1 A118G and alcohol sensitivity with intravenous alcohol self-administration in young adults.
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Individual differences in alcohol sensitivity were assessed using 1) a baseline self-report measure and 2) subjective responses during the CASE session. Baseline alcohol sensitivity was measured with the Alcohol Sensitivity Questionnaire (Bartholow et al., 2007; Bartholow et al., 2003). The ASQ lists 16 alcohol effects; 10 focus on experiences thought to be typical of the ascending limb of intoxication (e.g., “relaxed,” “talkative,” “buzzed”) and 6 on sedative effects (e.g., nausea, blackouts). Participants indicate whether they have experienced each effect when drinking. For items endorsed, participants list the minimum number of standard drinks after which the effect is noticed (for ascending limb items) or the maximum number of drinks that could be consumed before noticing the effect (descending limb items). The ASQ can be differentiated from other self-report measures of alcohol sensitivity by the use of 16 items covering presumed ascending and descending limb effects and the use of a single (current) recall time frame (Bartholow et al., 2007).