Chunk #0 — 1. Introduction

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Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives.

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Results from the Collaborative Study on the Genetics of Alcoholism (COGA) demonstrated highly significant associations between alcohol dependence (AD) and multiple single nucleotide polymorphisms (SNPs) and three-SNP-haplotypes in the GABRA2 gene (Edenberg et al., 2004), a gene which encodes the GABA A receptor alpha 2 subunit. These results were quickly replicated by two other groups (Covault et al., 2004; Lappalainen et al., 2005).