In conclusion, compared to Groups I–II, the eight Group III cases represented different medical and lifetime drug use histories and toxicological profiles ( Fig. 1 ). While the exact nature of these differences could not be causally linked to specific ante or postmortem factors, alcohol dependence appeared to be a primary diagnosis for 5/8 Group III cases, which along with no or low concentrations of cocaine, cannabis or phencyclidine and significant other medical problems may have led to opposite regulation in Group III of the 89 transcripts shared among all three groups, of 91/115 transcripts changed in both Group I and Group III, and of 79/81 transcripts changed in both Groups II and III.
