significant effects of ADH1B*2 on measures of intoxication and flushing. Several studies of Asians using alcohol challenge, retrospective self-report, and skin patch tests have reported ADH1B*2 is associated with increased alcohol-related symptoms (e.g., facial flushing, vomiting), but that this relationship is only signfiicant in individuals who also possess an ALDH2*2 allele (Cook et al., 2005; Takeshita et al., 1996; 2001; Yokoyama et al., 1999; 2003; although see Chen et al., 1998), suggesting it may be the combined effects of ALDH2*2 and ADH1B*2 that lead to more apparent associations of these alleles with response to alcohol.
