to regulate opioid tolerance (He & Wang, 2012). miRNAs are both synaptically enriched and depleted by drug exposure. Cocaine modulates levels of the miR-8 family which is enriched at postsynaptic densities and regulates expression of cell adhesion molecules (Eipper-Mains, Eipper, & Mains, 2012). Differential expression of multiple lncRNAs was identified in the NAc of cocaine-conditioned mice and those lncRNAs were reported to regulate their target loci through both cis- and trans-actions (Bu et al., 2012).
