noted as of interest, TMEM108 codes for a transmembrane protein of unknown function, but has previously been reported as associated with smoking cessation in a pooling GWAS study (45). SHANK2 is a scaffolding gene implicated in the formation of the postsynaptic density at glutamergic synapses, and there have been reports of rare SHANK2 variants overrepresented in cases of Autism Spectrum Disorder (46). For the remainder no obvious link with alcoholism risk can be identified. In no case do we have confidence that a true positive association has been identified; and because of small effect sizes, confirmation by the first generation of alcohol GWAS studies is not to be expected.
