The combination of bupropion plus the nicotine lozenge was also examined because of promising initial results with the nicotine lozenge as a monotherapy.17 Also, the combination of the nicotine patch + bupropion was found to be highly efficacious in the 2008 PHS Guideline meta-analysis (OR = 2.5).1 It is possible that an NRT that permits ad libitum dosing might produce even better outcomes.
