subsequent analyses – this avoids ascribing an unaffected status to an adolescent or young adult who may be at high genetic risk but not yet past the peak period of vulnerability. There were 684 subjects in the 118 extended families who met criteria for AD using either an adult or adolescent SSAGA (Table S1). Among 1638 remaining individuals, 964 were classified as unaffected. The average number of individuals in a family diagnosed with AD was 5.9 (Figure S2).
