Similar to volumetric difference analysis, based on FWER (α<0.05), FA and AD differences with p<0.0068, and RD differences with p<0.0064 were considered significant. Group differences in left and right (GM01/02) putamen, right superior longitudinal fasciculus (WM06), callosal body (WM07), and left superior corona radiata (WM10) were rendered nonsignificant after controlling for age (Table 2). Significant positive correlations between age and bilateral putamen (Left: R2=0.518; Right: R2=0.531), with a group-independent greater left than right asymmetry in the putamen FA [paired t(59)=10.04, p<0.0001], were also observed (Figure 4). In remaining 10 clusters, AUD participants had significantly lower FA in WM compared to controls, except in left thalamus (GM03) where the FA was higher in the AUD group (Table 2).
