phosphorylation in the cerebellum of wildtype mice, but not PKCε knockout mice and this leads to reduced GABAA receptor function in cerebellar microsacs (Qi et al. 2007). Finally, phosphorylation at serine327 on GABAA receptor γ2 subunits is required for PKCε-mediated modulation of GABAA receptor function (Qi et al. 2007). Further studies investigating post-translational modification of these receptors at PKC phosphorylation sites by specific PKC isoforms will lead to a better understanding of PKC-mediated effects of ethanol on GABAA receptors.
