In addition to ADH, the ethanol-inducible CYP2E1 is also expressed in breast tissue. CYP2E1 can activate procarcinogens, and also generates oxygen radicals, which can cause lipid peroxidation, as an integral part of its catalytic activity (Caro and Cederbaum, 2004). Elevated levels of CYP2E1 were recently shown to increase levels of mutagenic DNA adducts in the esophagus, another target tissue for alcohol-related carcinogenesis (Millonig et al., 2011).
