Chunk #21 — Results — dCas9−VP64 Transcript Induction Efficacies Are Not Necessarily Consistent between NPCs, Neurons, Astrocytes, and HEK293T Cells

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Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes.

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We recommend validating gRNA efficacy across not just each individual hiPSC line to be evaluated and each dCas9 effector to be employed, but also each cell type to be characterized.