in the expression levels of tightly co-regulated genes, in agreement with previous work in yeast [9]. creQTL may be better-suited to the identification of the strongest trans drivers of gene expression because it better explains the data; i.e., genes do not work individually to exert their biological effects, but rather in tightly coordinated groups. However, our results regarding the location of these drivers of co-regulation relative to coding sequences suggests that they might be disjoint from cis drivers of individual gene expression.
