We were unable to replicate the genome-wide significant loci identified in the recent CONVERGE study6 although we identified modest associations in each region (LHPP, rs145655839, minimum p-val= 0.0024 out of 6,204 SNPs in the region, and SIRT1, rs187810158, minimum p-val=0.0102 out of 5,111 SNPs in the region). This is unsurprising given that our study looked for genetic determinants of susceptibility in both males and females of European descent, and likely represented a very different population structure than that of the CONVERGE study of Han Chinese women.
