In a recent analyses of a group of 70 COS children followed from age 8 to 28, the pattern of GM deficits became more restricted to the prefrontal and superior temporal cortices by age 26, further establishing continuity with the adult-onset disorder (Greenstein et al., 2006). Mild frontal and temporal GM deficits are also found in those at genetic risk for schizophrenia and have even been associated with specific genotypes (Cannon et al., 2005). Similar brain changes have also been tracked as psychosis develops in those at risk (Pantelis et al., 2007).
