the negative control regions, and modestly significant in ASN (<p = 2x10-7 and p = 0.01 for EUR and ASN, respectively) and appears inconsistent with the null hypothesis of neutral evolution and demography at the LCT locus especially in the EUR populations. In contrast, the histogram for AFR shows few windows with extreme Tajima’s D values. Indeed, the proportion of windows with extreme values was <1% and was not significantly different from the negative controls, therefore we are unable to reject the null hypothesis of neutral evolution and demography at this locus in AFR.
