We investigated genetic correlations between depression and other phenotypes available at LD Hub39 and in-house, including 258 published GWASs and 597 GWAS results for UKB traits. Depression was significantly correlated (P<2 x 10−4) with 364 phenotypes representing several domains and confirmed previous observations12-15,40-45 (Supplementary Table S5A and Figure S8A). Among psychiatric disorders, depression showed significant correlation with e.g., ADHD (rg=0.56, SE=0.022, P=1 x 10−135), autism (rg=0.35, SE=0.033, P=6.5 x 10−24), bipolar disorder (rg=0.31, SE=0.033, P=3 x 10−18), schizophrenia (rg=0.33, SE=0.021, P=4 x 10−53), anxiety (rg=0.79, SE=0.017, P=3.2 x 10−193), alcohol dependence (rg=0.65, SE=0.097, P=4.3 x 10−9) and cannabis use disorder (rg=0.44, SE=0.036, P=2.2 x 10−31). In UKB data, the three strongest genetic correlations were seen for the phenotypes: “Seen doctor (GP) for nerves_ anxiety_ tension or depression”, “Mood swings” and “Miserableness” (rg=0.96, 0.71, 0.71, respectively; Supplementary Table S5B and Figure S8B).
