χ2< 0.001, RMSEA < 0.001, WRMR = 0.40, CFI = 1.00). The indirect pathway from the GxE interaction to cannabis dependence symptoms through using cannabis to control mood was also significant (bIND = -1.71, 95% CI [-3.26, -0.21], p = .029). Analyses of indirect effects within genotype groups revealed that the indirect effect of CSA on cannabis dependence symptoms through using cannabis to control mood was significant only among G allele homozygotes (GG: bIND = 1.85, 95% CI [1.17, 2.47], p < .001; AA/AG: bIND = 0.13, 95% CI [-1.24, 1.27], p = .851). These results are consistent with the proposed hypothesis of differential sensitization to stress across rs604300 genotypes leading to stress-related coping with cannabis and thus susceptibility to dependence.
