particularly relevant for identifying the function of risk variants for common diseases: for example study immune tissues for immune-mediated diseases, adipose tissue for obesity traits [8], brain tissue for neurological traits [10]. Genetical genomics experiments performed in outbred human populations are additionally complex and in addition to tissue specific RNA profiles, care should be taken to investigate alternative RNA sequence events, primer polymorphisms that generate false eQTLs and strong cis-eQTLs that obscure weaker trans effects.
