receipt of reward during fMRI paradigms (Dreher et al., 2009; Forbes et al., 2009), suggesting that greater synaptic DA availability might underlie reward salience. While nine VNTR carriers also were reported to have greater ventral striatal responses to smoking cues (Franklin et al., 2009; Franklin et al., 2011), to our knowledge this has not been explored with alcohol consumption or cues and/or how it might predict medication response.