signals (26). By applying a Bonferroni correction for multiple testing (assuming 118 independent bins), values of PSR, 0.05/118=0.00042 and 1/118=0.0085 correspond to the genomewide significant and suggestive evidence for linkage, respectively. Simulation studies have shown that these thresholds are appropriate for the GSMA (28), with a P-value exceeding the genomewide significant threshold expected once by chance in 20 meta-analyses and a P-value exceeding the genomewide suggestive threshold expected once by chance per single meta-analysis.
