Chunk #12 — Methods — Overview of cell type enrichment analyses

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Comprehensive analyses of RNA-seq and genome-wide data point to enrichment of neuronal cell type subsets in neuropsychiatric disorders.

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Finally, additional human and mouse scRNA datasets (Table S2) were used to conduct additional cell type enrichment analysis, using FUMA (version 1.3.6a) [29] (Supplementary Methods). FUMA builds on MAGMA (version 1.08). However, FUMA includes averaged expression per gene across cell type as covariate in their model instead of Sg,c and was therefore not included in our main analyses but as confirmational cell type enrichment analysis.