Two optional surveys were designed to augment data contained in the electronic health record. The MVP Baseline Survey elicits information regarding demographic factors, family pedigree, health status, lifestyle habits, military experience, medical history, family history of specific illnesses, and physical features. The MVP Lifestyle Survey contains questions from validated instruments, in domains selected to provide information on environmental exposures, dietary and other habits, sleep and exercise habits, and sense of well-being. This latter instrument includes the following item: “In a typical month, what is/was the largest number of drinks of alcohol (beer, wine, and/or liquor) you may have had in one day?” The response to this item was used to define the phenotype in the present study, referred to here as MaxAlc. All EUR and AFR subjects who responded to the questionnaire were included. Differences between respondents and non-respondents among MVP participants are shown in Supplementary Table 1.
