higher than in the brain tissues derived from non-alcoholic subjects. Another gene of interest, CXCR7 in chromosome 2q37.3, encodes C-X-C chemokine receptor type 7, a member of the G-protein coupled receptor family. Our preliminary assay with human frontal cortices showed CXCR7 total mRNA expression is 1.33 fold higher in alcoholics, compared to the expression level in non-alcoholic subjects. The method of these assays is included in the supplementary information.