be to re-estimate the local correlation after the removal of the smaller region of GW signal from the original datasets. When we conducted this analysis for the SZ-CD pair, we found that the number of significant loci (BH p < 0.05) was reduced from 32 to 8, suggesting that GW hits likely play an important role in many of the local genetic correlations. Future studies will be able to combine larger GWAS sample sizes with new methods aimed at stratifying genetic correlations by biological annotations (e.g., tissue type or signaling pathways) in order to more precisely define the parts of the genome that mediate a genetic correlation (Lu et al. 2017).
