Genome-wide association studies (GWASs) of alcohol consumption have found few consistently replicable loci outside of the alcohol metabolizing genes. A GWAS of alcohol consumption comprising 47 501 individuals of European ancestry found rs6943555 in AUTS2 to be associated with alcohol consumption.14 This locus did not replicate in a more recent GWAS of alcohol consumption in >105 000 European individuals. However, a SNP in KLB was associated with alcohol consumption in humans and the gene product, β-klotho, was found to regulate alcohol preference in mice.15
