Parameter estimates from the full model that included PRS, marital status, the two-way interactions, and the three-way interaction between PRS, marital status, and age are summarized in Table 4. We found a significant negative three-way interaction between PRS, marital status, and age, and we focus on the interpretation of this three-way interaction effect in view of the fact that this higher-order interaction modifies the main effects and lower-order interactions. Figure 1 depicts the pattern of the three-way interaction between PRS, marital status, and age, plotted at three illustrative ages (21, 23, and 25). Each plot shows the expected frequencies of HED by combinations of marital status and PRS, which was split at the median.
