compare the duration and the pattern of PFC activation following acute drug exposure and following exposure to conditioned cues in the same subjects. Studies in non-addicted individuals could be used to assess the impact of deprivation (for example, of food) and urgent needs (for example, hunger, sexual desire and achievement motivation) on PFC cue reactivity. For example, in young healthy controls, craving of imagined foods — induced by a monotonous diet — was associated with activation in several limbic and paralimbic regions, including ACC (Brodmann area 24)58.
