The trans-ancestral (EA+AA) analyses identified rs1890881 as genome-wide significant (Figure 3). The SNP is in an intron of RABGAP1L; however, it is also an eQTL for several neighboring genes. According to the GTEx (v7) database, rs1890881 is an eQTL for 7 genes (48 signals), that included several signals in brain tissue (Supplemental Table S2). rs1890881 also made chromatin contact with several of these genes, including SERPINC1 (Supplemental Figure S6; genes identified using eQTL and chromatin interaction mapping are in red) as well as other distal contacts across tissues. There was no support for independent loci in the region in either ancestral group (Supplemental Figure S5D and S5E).
